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CHAPTER FOUR






                 The Laparoscopic Revolution in
                 Metabolic Bariatric Surgery



                 Luigi Angrisani, Francesco Angrisani, Francesco Saverio Papadia,
                 Nicola Di Lorenzo, Maurizio De Luca









                 Laparoscopic techniques are now  the standard of care for metabolic bariatric surgery (MBS)
                 procedures worldwide. This brief account traces the early stages of this remarkable transformation,
                 in which Professor Luigi Angrisani was a participant at the end of the last century.
                 In 1995, a meeting between  Angrisani and Professor Nicola Scopinaro initiated a professional
                 relationship that quickly evolved into a close friendship. The occasion was the first hands-on MBS
                                      TM
                 course on the Lap-Band , sponsored by the Inamed company, held in Todi, a small medieval town
                 in  Umbria,  central  Italy.  At  that  time,  Scopinaro  was  already  a  giant  in  the  field,  internationally
                 renowned, and Angrisani, a young and enthusiastic “laparoscopic surgeon” eager to learn more
                 about obesity.

                 Dr.  Alan  Wittgrove had already demonstrated the feasibility of laparoscopic Roux-en-Y gastric
                 bypass (RYGB), the Lap-Band was beginning its rise to prominence, and laparoscopic vertical
                 banded gastroplasty (VBG) was being performed in only a few centers. MBS, itself, was still a niche
                 field,  and  most  surgeons  considered  obesity  a  relative  contraindication  for  laparoscopic
                 approaches. In January 1996, Angrisani initiated a laparoscopic surgery obesity program at the
                 Department of Surgery of Federico II University in Naples, performing adjustable gastric banding
                 (AGB).  Over the following three years, he chaired a  national meeting that gathered the  Italian
                 experience in this field, with the active participation of Scopinaro and many leading Italian surgeons.
                 The Lap-Band device had been approved for marketing in Europe and worldwide, but not in the
                 United States (US). Suboptimal results of trials conducted in the US were not well received by the the
                 Food and Drug  Administration (FDA), which denied approval at that time, preventing its
                 commercialization there.
                 Meanwhile, laparoscopic surgery for obesity was expanding rapidly, with exponential growth
                 resembling “another French Revolution,” as it was referenced colloquially, that followed the prior
                 introduction of laparoscopic cholecystectomy in Germany and France. It was a period of
                 unprecedented  enthusiasm in  general  surgery.  Strong support  also  came  from international
                 companies that introduced new devices, systems, and technologies; they promoted courses,
                 meetings, and congresses globally to foster continuous education and updates in the evolving field.
                 As laparoscopy spread across all disciplines of abdominal surgery, more than 90% of MBS
                 procedures performed globally were AGB operations, which were broadly indicated for nearly all
                 patients with obesity.

                 Despite his deep respect for Nicola as a man, scientist, and surgeon, Angrisani was convinced that
                 laparoscopic techniques would eventually replace open surgery for all MBS procedures. Scopinaro






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